| Date | Age | Event | Bishop | Title | Current Title |
| unknown | 80.0 | Died | Antonio del Aguila Vela y Paz † | Bishop of Zamora, Spain |
| Born | Richard Arthur † | Cork | Bishop of Limerick, Ireland |
| Died | Girolamo Beccadelli Bologna † | Bishop of Siracusa, Italy |
| 58.0 | Resigned | Ugo Boncompagni † | Bishop of Vieste, Italy | Pope (Roma {Rome}, Italy) |
| Died | Giambatista Borgia † | Bishop of Massa Lubrense, Italy |
| Died | Angelo Bragadin, O.P. † | Bishop of Vicenza, Italy |
| Born | Giacomo Antonio Caporali † | | Bishop of Minervino Murge, Italy |
| Born | Pietro Capullio, O.F.M. Conv. † | Cortonae | Bishop of Conversano, Italy |
| Died | Giacomo Antonio Carrozza † | Bishop of Conversano, Italy |
| Died | Leonello Cibo (Cybo) † | Bishop Emeritus of Penne e Atri, Italy |
| Died | Francesco Colonna † | Archbishop of Taranto, Italy |
| 36.8 | Resigned | Gianfrancesco Commendone † | Bishop of Cefalonia e Zante, Greece | Cardinal, Bishop Emeritus |
| Born | Tomeo Confetto † | | Bishop of Muro Lucano, Italy |
| Born | Ottavio Acquaviva d’Aragona (Sr.) † | Naples | Cardinal, Archbishop of Napoli {Naples}, Italy |
| Born | Jean Dauvin † | | Bishop of Namur {Namen}, Belgium |
| Born | Domingo (Pedro) de Oña, O. de M. † | Burgos, Spain | Bishop of Gaeta, Italy |
| Born | Bertrand d’Eschaux (de Chaux) † | Béarn | Archbishop of Tours, France |
| Died | Pablo de Torres, O.P. † | Bishop of Panamá |
| Appointed | Giovanni Pietro Dolfin † | Bishop of Cefalonia e Zante, Greece |
| Born | Lorenz Eiszepf † | Freising | Auxiliary Bishop of Eichstätt, Germany |
| Born | Juan (Giovanni) de Espila (Spilla), O.P. † | Deva, Spain | Archbishop of Acerenza e Matera, Italy |
| 39.2 | Appointed | Alessandro Farnese (Jr.) † | Administrator of Avignon, France | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| Died | Giacomo Antonio Ferduzi, O.F.M. Conv. † | Bishop of Martirano (Martoranum), Italy |
| Died | Antonio Filonardi † | Bishop of Veroli, Italy |
| Born | Virgilio Fiorenti † | | Bishop of Nocera Umbra, Italy |
| Resigned | Giulio Galletti † | Bishop of Alessano, Italy | Bishop Emeritus |
| Resigned | Giulio Giovio † | Bishop of Nocera de’ Pagani, Italy | Bishop Emeritus |
| Succeeded | Paolo Giovio (il Giovane) † | Bishop of Nocera de’ Pagani, Italy |
| Resigned | Giulio de Grandis † | Bishop of Anglona-Tursi, Italy | Bishop Emeritus |
| Born | Vittorio Guarini † | | Bishop of Anagni, Italy |
| Born | Francisco García Guerra, O.P. † | Palencia, Spain | Archbishop of México, Federal District |
| Born | Roland Hébert † | Beaumont-sur-Oise | Archbishop of Bourges, France |
| Died | Rostaing de La Baume de Suze, O. Cist. † | Bishop of Orange, France |
| Appointed | Gaspar de Leão Pereira † | Archbishop of Goa, India |
| Born | Christophe de L’Estang † | Brive | Bishop of Carcassonne, France |
| 48.0 | Appointed | Giovanni Francesco Lottini † | Bishop of Conversano, Italy | Bishop Emeritus |
| Born | Valerianus Łubieniecki, O.F.M. † | | Bishop of Bacău, Romania |
| Born | Placido Marra † | Naples | Bishop of Melfi e Rapolla, Italy |
| Resigned | Borso Merli † | Bishop of Bobbio, Italy | Bishop Emeritus |
| Born | Alfonso Manrique † | | Archbishop of Burgos, Spain |
| Died | Sébastien di Montfalcon (Montfaucon) † | Bishop of Lausanne, Switzerland |
| 24.0 | Ordained Priest | Sebastião de Morais de Funchal, S.J. † | Priest of Society of Jesus | Bishop of Funay (Funai), Japan |
| Born | Pedro Ordóñez y Flórez † | Brozas, Spain | Archbishop of Santafé en Nueva Granada, Colombia |
| Died | Ferdinando Pandolfini † | Bishop of Troia, Italy |
| Born | Alessandro Papatodoro † | | Bishop of Belcastro, Italy |
| Died | Silverio Petrucci † | Bishop of Muro Lucano, Italy |
| Died | Caesar Podocathor † | Archbishop of Nicosia, Cyprus |
| Died | Dionisio de Robertis † | Archbishop of Manfredonia, Italy |
| Born | Gérard de Robin, O.S.A. † | | Bishop of Lodève, France |
| Born | Giovanni Battista Salvago † | Genova | Bishop of Luni e Sarzana, Italy |
| Confirmed | Moritz von Sandizell † | Bishop of Freising, Germany | Bishop Emeritus |
| Born | Giacomo Sannesio † | Belforte | Cardinal, Bishop of Orvieto, Italy |
| Appointed | Giovanni Trevisan † | Patriarch of Venezia {Venice}, Italy |
| 13.0 | Professed | Fernando Trexo y Senabria, O.F.M. † | Member of Order of Friars Minor | Bishop of Córdoba (Tucumán), Argentina |
| Born | Antonio Valente, O.P. † | Lisbonne, Portugal | Bishop of São Tomé e Príncipe |
| Appointed | Jérôme de Valperga † | Archbishop of Tarentaise (Moûtiers-en-Tarentaise), France |
| Born | Fabrizio Verallo † | Rome | Cardinal, Bishop Emeritus of San Severo, Italy |
| Died | Marco Quinto Vigerio della Rovere † | Bishop Emeritus of Senigallia, Italy |
| 29.0 | Resigned | Vitellozzo Vitelli † | Bishop of Città di Castello, Italy | Cardinal, Bishop Emeritus |
| Born | Christoph Weber † | Seligenstadt | Auxiliary Bishop of Mainz, Germany |
| Born | Paweł Wołucki † | | Bishop of Włocławek (Kujawy, Kalisze), Poland |
| 6 Jan | 60.8 | Installed | Giovanni Angelo de’ Medici † | Pope (Roma {Rome}, Italy) |
| 12 Jan | | Died | John White † | Bishop of Winchester, England, Great Britain |
| 16 Jan | 78.0 | Appointed | Jean Bertrand † | Cardinal-Priest of Santa Prisca | Cardinal, Bishop Emeritus of (Saint-Bernard de) Comminges, France |
| 47.5 | Appointed | Cristoforo Madruzzo † | Cardinal-Priest of San Crisogono | Cardinal, Bishop of Brixen {Bressanone}, Italy |
| 19 Jan | 42.0 | Appointed | Giovanni Andrea Mercurio † | Cardinal-Priest of San Marcello | Cardinal, Archbishop of Messina, Italy |
| 37.0 | Appointed | Giacomo Savelli † | Cardinal-Priest | Cardinal, Cardinal-Bishop of Porto e Santa Rufina |
| 21 Jan | | Appointed | Ippolito Capilupo † | Bishop of Fano, Italy | Bishop Emeritus |
| 25 Jan | 37.1 | Ordained Priest | Giacomo Savelli † | Priest | Cardinal, Cardinal-Bishop of Porto e Santa Rufina |
| 26 Jan | 47.5 | Appointed | Diego de Covarrubias y Leiva † | Archbishop (Personal Title) of Ciudad Rodrigo, Spain | Bishop of Cuenca, Spain |
| 32.1 | Appointed | Girolamo della Rovere † | Bishop of Toulon, France | Cardinal, Archbishop of Torino {Turin}, Italy |
| 40.5 | Appointed | Giovanni Antonio Facchinetti de Nuce † | Bishop of Nicastro, Italy | Pope (Roma {Rome}, Italy) |
| Appointed | Marco Lauro, O.P. † | Bishop of Satriano e Campagna, Italy |
| Died | Feliks Ligęza † | Archbishop of Lviv, Ukraine |
| 51.1 | Appointed | Leonardo Marini, O.P. † | Bishop of Lanciano, Italy | Bishop Emeritus of Alba (Pompea), Italy |
| Appointed | Juan Battista (Giovanni Battista) de Ojeda (Hogeda, Oxeda) † | Archbishop of Trani, Italy | Bishop of Agrigento (Girgenti), Italy |
| Appointed | Filip Padniewski † | Bishop of Przemyśl, Poland | Bishop of Kraków, Poland |
| Appointed | Pompeo Piccolomini † | Bishop of Tropea, Italy |
| 50.1 | Appointed | Pedro Ponce de Léon † | Bishop of Plasencia, Spain |
| 37.1 | Resigned | Giacomo Savelli † | Administrator of Nicastro, Italy | Cardinal, Cardinal-Bishop of Porto e Santa Rufina |
| 31 Jan | 21.3 | Elevated to Cardinal | St. Charles Borromeo † | Cardinal, Archbishop of Milano {Milan}, Italy |
| 42.8 | Appointed | Carlo Carafa † | Cardinal, Cardinal-Deacon of San Nicola in Carcere |
| 15.3 | Elevated to Cardinal | Giovanni de’ Medici (Jr.) † | Cardinal, Apostolic Administrator of Pisa, Italy |
| Confirmed | Johann Gebhard von Mansfeld † | Archbishop of Köln {Cologne}, Germany | Archbishop-Elect |
| 41.1 | Elevated to Cardinal | Giovanni Antonio Serbelloni † | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| Feb | 32.8 | Confirmed | Johann Leisentrit † | Prefect of Meißen (Meissen) {Lusazia o Lausitz; Sassonia}, Germany |
| 6 Feb | | Appointed | Mariano Savelli † | Bishop of Gubbio, Italy |
| 7 Feb | | Appointed | Costantino Bonelli † | Bishop of Città di Castello, Italy |
| 21.3 | Appointed | St. Charles Borromeo † | Administrator of Milano {Milan}, Italy | Cardinal, Archbishop |
| 25.1 | Appointed | Guillaume de St-Marcel d’Avançon † | Archbishop of Embrun, France |
| 75.1 | Appointed | Robert de Lénoncourt † | Cardinal, Archbishop of Arles, France |
| 75.1 | Resigned | Robert de Lénoncourt † | Archbishop of Embrun, France | Cardinal, Archbishop of Arles, France |
| 75.1 | Resigned | Robert de Lénoncourt † | Administrator of Auxerre, France | Cardinal, Archbishop of Arles, France |
| 33.1 | Appointed | Philippe de Lénoncourt † | Bishop of Auxerre, France | Cardinal, Bishop Emeritus |
| Appointed | Donagh O’Tighe † | Archbishop of Armagh, Ireland |
| Appointed | Sante Sacco † | Bishop of Bisignano, Italy |
| 29.1 | Appointed | Vitellozzo Vitelli † | Administrator of Imola, Italy | Cardinal, Bishop Emeritus of Città di Castello, Italy |
| 14 Feb | 21.4 | Installed | St. Charles Borromeo † | Cardinal-Deacon of Santi Vito, Modesto e Crescenzia | Cardinal, Archbishop of Milano {Milan}, Italy |
| Appointed | Matteo Concini † | Bishop of Cortona, Italy | Bishop Emeritus |
| Appointed | Giovambattista Ricasoli † | Bishop of Pistoia, Italy |
| 41.1 | Installed | Giovanni Antonio Serbelloni † | Cardinal-Priest of San Giorgio in Velabro | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| Appointed | Stanisław Słomowski (Szbomowski) † | Auxiliary Bishop of Kraków, Poland | Archbishop of Lviv, Ukraine |
| Appointed | Stanisław Słomowski (Szbomowski) † | Titular Bishop of Laodicea in Phrygia | Archbishop of Lviv, Ukraine |
| Appointed | Giulio (Egidio) Soperchio, O. Carm. † | Bishop of Acci (Accia), France | Bishop of Caorle, Italy |
| 16 Feb | 68.1 | Died | Jean du Bellay † | Cardinal, Bishop Emeritus of Paris, France |
| 17 Feb | | Died | Antoine Olivier † | Bishop of Lombez, France |
| 5 Mar | 71.7 | Died | Pedro Pacheco de Villena (Ladrón de Guevara) † | Cardinal, Bishop of Sigüenza, Spain |
| 6 Mar | | Died | Joannes Monichusen † | Bishop of Ösell (Oesell) [Saare-Lääne], Estonia |
| 13 Mar | | Appointed | Hieronymus Beliardus † | Titular Bishop of Constantia in Arabia |
| 78.2 | Appointed | Jean Bertrand † | Cardinal-Priest of San Crisogono | Cardinal, Bishop Emeritus of (Saint-Bernard de) Comminges, France |
| Appointed | Ventura Buralini † | Bishop of Massa Marittima, Italy |
| 59.7 | Resigned | Federico Cesi † | Administrator of Cremona, Italy | Cardinal, Cardinal-Bishop of Porto e Santa Rufina |
| 58.7 | Appointed | Clemente d’Olera, O.F.M. Obs. † | Cardinal, Bishop of Foligno, Italy |
| Appointed | Cesare Gesualdo † | Bishop of Mottola (Motula), Italy |
| 75.2 | Appointed | Robert de Lénoncourt † | Cardinal-Bishop of Sabina | Cardinal, Archbishop of Arles, France |
| Appointed | Kaspar von Logau † | Bishop of Wiener Neustadt, Austria | Bishop of Wrocław (Breslau), Poland |
| 47.7 | Appointed | Cristoforo Madruzzo † | Cardinal-Priest of Santa Maria in Trastevere | Cardinal, Bishop of Brixen {Bressanone}, Italy |
| Appointed | Filippo Mocenigo † | Archbishop of Nicosia, Cyprus |
| 51.1 | Appointed | Giovanni Gerolamo Moroni (Morone) † | Cardinal-Bishop of Albano | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| 51.1 | Resigned | Giovanni Gerolamo Moroni (Morone) † | Bishop of Novara, Italy | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| Appointed | Giovanni Fabrizio Sanseverino † | Bishop of Acerra, Italy | Bishop of Trivento, Italy |
| 41.2 | Appointed | Giovanni Antonio Serbelloni † | Bishop of Novara, Italy | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| 25.1 | Appointed | Niccolò Sfondrati † | Bishop of Cremona, Italy | Pope (Roma {Rome}, Italy) |
| 71.2 | Appointed | François de Tournon, C.R.S.A. † | Cardinal-Bishop of Ostia (e Velletri) | Cardinal, Archbishop of Lyon, France |
| 27 Mar | 28.8 | Appointed | Federico Cornaro (Sr.), O.S.Io.Hieros. † | Bishop of Trogir (Traù), Croatia | Cardinal, Bishop of Padova {Padua}, Italy |
| Appointed | Girolamo Gallarati † | Bishop of Nepi e Sutri, Italy | Bishop of Alessandria (della Paglia), Italy |
| 56.2 | Appointed | St. Antonio (Michele) Ghislieri, O.P. † | Bishop of Mondovi, Italy | Pope (Roma {Rome}, Italy) |
| Appointed | Brandelisio Trotti † | Bishop of Saint-Jean-de-Maurienne, France |
| 3 Apr | | Born | Ascanio Colonna † | | Cardinal, Cardinal-Bishop of Palestrina |
| 5 Apr | 60.3 | Appointed | Julião de Alva † | Bishop of Miranda (do Douro), Portugal | Bishop Emeritus |
| Appointed | Giovanni Paolo Amanio † | Bishop of Anglona-Tursi, Italy |
| Appointed | Andrés de Noronha † | Bishop of Portalegre, Portugal | Bishop of Plasencia, Spain |
| 34.1 | Resigned | Niccolò Caetani di Sermoneta † | Administrator of Quimper, France | Cardinal, Archbishop of Capua, Italy |
| 15 Apr | | Ordained Bishop | Gaspar de Leão Pereira † | Archbishop of Goa, India |
| Ordained Bishop | Jorge Temudo, O.P. † | Bishop of Cochin, India | Archbishop of Goa, India |
| 17 Apr | | Ordained Bishop | Costantino Bonelli † | Bishop of Città di Castello, Italy |
| 26 Apr | 19.8 | Appointed | Alfonso Carafa † | Cardinal-Priest of Santi Giovanni e Paolo | Cardinal, Archbishop of Napoli {Naples}, Italy |
| 77.3 | Appointed | Fernando de Loaces (Loazes), O.P. † | Archbishop of Tarragona, Spain | Archbishop of Valencia, Spain |
| 15.6 | Appointed | Giovanni de’ Medici (Jr.) † | Cardinal-Deacon of Santa Maria in Domnica | Cardinal, Apostolic Administrator of Pisa, Italy |
| Appointed | Domenico di Grammatica † | Bishop of Santorini {Thira}, Greece |
| Appointed | Jean Hennuyer † | Bishop of Lisieux, France |
| 41.4 | Resigned | Guido Ascanio Sforza di Santa Fiora † | Administrator of Parma, Italy | Cardinal, Chamberlain (Camerlengo) of the Apostolic Chamber |
| 26.3 | Appointed | Alessandro Sforza † | Bishop of Parma, Italy | Cardinal, Bishop Emeritus |
| 57.3 | Appointed | Jean Suau † | Cardinal-Priest of Santa Prisca | Cardinal, Bishop Emeritus of Mirepoix, France |
| 28 Apr | 47.8 | Ordained Bishop | Diego de Covarrubias y Leiva † | Bishop of Ciudad Rodrigo, Spain | Bishop of Cuenca, Spain |
| Died | Diego Tavera Ponce de Léon † | Bishop of Jaén, Spain |
| 1 May | | Ordained Bishop | Filippo Mocenigo † | Archbishop of Nicosia, Cyprus |
| 6 May | | Born | Guido Pepoli † | Bologna, Italy | Cardinal, Cardinal-Priest of San Pietro in Montorio |
| 13 May | 31.4 | Confirmed | Marquard von Hattstein † | Coadjutor Bishop of Speyer, Germany | Bishop |
| 15 May | | Died | Francisco de Santa María Benavides Velasco, O.S.H. † | Bishop of Segovia, Spain |
| 25 May | | Died | Andrzej Zebrzydowski † | Bishop of Kraków, Poland |
| 26 May | | Died | Étienne Martel de Bacqueville † | Bishop of Coutances, France |
| 29 May | | Appointed | Giovanni Battista Alamanni † | Bishop of Mâcon, France |
| Appointed | Antonio Cocco † | Coadjutor Archbishop of Corfù, Greece | Archbishop Emeritus |
| 26.8 | Appointed | Mark Sittich von Hohenems (Altemps) † | Bishop of Cassano all’Jonio, Italy | Cardinal, Bishop Emeritus of Konstanz {Constance}, Germany |
| Appointed | Niccolò Tornabuoni † | Bishop of Sansepolcro (Borgo San Sepolcro), Italy |
| 19 Jun | 15.7 | Appointed | Giovanni de’ Medici (Jr.) † | Cardinal, Apostolic Administrator of Pisa, Italy |
| 56.4 | Appointed | Scipione Rebiba † | Archbishop (Personal Title) of Troia, Italy | Cardinal, Cardinal-Bishop of Sabina |
| Appointed | Benedetto Salino † | Bishop of Veroli, Italy |
| 20 Jun | | Ordained Bishop | Ippolito Capilupo † | Bishop of Fano, Italy | Bishop Emeritus |
| 21 Jun | 31.5 | Succeeded | Marquard von Hattstein † | Bishop of Speyer, Germany |
| 36.5 | Died | Rudolf von Frankenstein † | Bishop of Speyer, Germany |
| 26 Jun | | Appointed | Pedro González Mendoza † | Bishop of Salamanca, Spain |
| 57.5 | Appointed | Francisco Manrique de Lara † | Bishop of Sigüenza, Spain |
| 27 Jun | | Appointed | Andrea Belloni † | Bishop of Massa Lubrense, Italy |
| 29 Jun | 49.7 | Appointed | Guillermo Casador † | Coadjutor Bishop of Barcelona, Spain | Bishop |
| 49.7 | Appointed | Guillermo Casador † | Titular Bishop of Xanthe | Bishop of Barcelona, Spain |