| Date | Age | Event | Bishop | Title | Current Title |
| unknown | | Died | Juan Francisco de Aguirre † | Bishop of Tropea, Italy |
| Born | Antonio Caetani (Jr.) † | Rome | Cardinal, Archbishop of Capua, Italy |
| 33.0 | Appointed | Pierre de Gondi † | Bishop of Langres, France | Cardinal, Bishop Emeritus of Paris, France |
| Born | Diego Guzmán de Haros † | Ocaña | Cardinal, Archbishop of Sevilla {Seville}, Spain |
| 38.3 | Confirmed | John Leslie † | Bishop of Ross, Ireland |
| Died | Diego Gilberto Nogueras † | Bishop of Alife, Italy |
| 44.1 | Appointed | Felice Peretti Montalto, O.F.M. Conv. † | Bishop of Sant’Agata de’ Goti, Italy | Pope (Roma {Rome}, Italy) |
| 62.0 | Appointed | Scipione Rebiba † | Archbishop of Pisa, Italy | Cardinal, Bishop of Sabina e Poggio Mirteto, Italy |
| 34.0 | Appointed | Giulio della Rovere † | Cardinal, Bishop of Ravenna, Italy |
| Born | Wilhelm Rinck von Balderstein † | | Bishop of Basel, Switzerland |
| Born | Galeazzo Sanvitale † | | Archbishop Emeritus of Bari (-Canosa), Italy |
| Appointed | Prosper de Sainte-Croix † | Archbishop of Arles, France |
| 59.4 | Appointed | Franciscus Sonnius (Van de Velde) † | Bishop of ’s Hertogenbosch (Bois-le-Duc), Netherlands | Bishop of Antwerpen {Antwerp}, Belgium |
| Born | Michelangelo Tonti † | Rimini | Cardinal, Archbishop (Personal Title) of Cesena, Italy |
| 46.5 | Ordained Priest | Veit von Würtzburg † | Priest of Bamberg, Germany | Bishop |
| 7 Jan | 62.0 | Elected | St. Antonio (Michele) Ghislieri, O.P. † | Pope (Roma {Rome}, Italy) |
| 17 Jan | 62.0 | Installed | St. Antonio (Michele) Ghislieri, O.P. † | Pope (Roma {Rome}, Italy) |
| 8 Feb | 51.4 | Installed | Prospero Publicola de Santa Croce † | Cardinal-Priest of S. Girolamo dei Croati (degli Schiavoni) | Cardinal, Bishop of Albano, Italy |
| 9 Feb | 43.3 | Ordained Priest | Gabriele Paleotti † | Priest of Bologna, Italy | Cardinal, Archbishop |
| 10 Feb | 43.3 | Ordained Bishop | Gabriele Paleotti † | Cardinal, Archbishop of Bologna, Italy |
| 15 Feb | | Appointed | Francisco de Abrego † | Bishop of Panamá |
| Appointed | Juan de Arzolaras (Alzóloras), O.S.H. † | Archbishop of Santo Domingo, Dominican Republic | Bishop of Islas Canarias {Canary Islands}, Spain |
| 18 Feb | 83.1 | Appointed | Fernando de Loaces (Loazes), O.P. † | Patriarch | Archbishop of Valencia, Spain |
| 12 Mar | | Born | Gregorio Parcero de Castro, O.S.B. † | Tuy | Bishop of Tortosa, Spain |
| 33.8 | Ordained Bishop | Giulio Antonio Santorio † | Cardinal, Archbishop of Santa Severina, Italy |
| 17 Apr | 15.3 | Professed | Alonso Orozco Enriquez de Armendáriz Castellanos y Toledo, O. de M. † | Member of Order of Our Lady of Mercy | Bishop of Michoacán, Michoacán, México |
| 26 Apr | 52.3 | Appointed | Francisco Delgado López † | Bishop of Jaén, Spain |
| Appointed | Diego Deza Tello † | Bishop of Coria, Spain | Bishop of Jaén, Spain |
| 28 Apr | 46.9 | Ordained Bishop | Veit von Würtzburg † | Bishop of Bamberg, Germany |
| 8 May | 27.4 | Resigned | Sigismund Markgraf von Brandenburg † | Archbishop of Magdeburg, Germany | Archbishop-Elect Emeritus |
| 27.4 | Resigned | Sigismund Markgraf von Brandenburg † | Bishop of Foreign Diocese | Archbishop-Elect Emeritus of Magdeburg, Germany |
| 15 May | 33.4 | Confirmed | Pierre de Gondi † | Bishop of Langres, France | Cardinal, Bishop Emeritus of Paris, France |
| Appointed | Antonio Ruíz de Morales y Molina, O.S. † | Bishop of Michoacán, Michoacán, México | Bishop of Tlaxcala, Tlaxcala, México |
| Appointed | Bartolomé Torres † | Bishop of Islas Canarias {Canary Islands}, Spain |
| 19 May | 33.4 | Ordained Bishop | Pierre de Gondi † | Bishop of Langres, France | Cardinal, Bishop Emeritus of Paris, France |
| 10 Jun | 45.4 | Appointed | Matthais Ob † | Auxiliary Bishop of Speyer, Germany |
| 45.4 | Appointed | Matthais Ob † | Titular Bishop of Daulia | Auxiliary Bishop of Speyer, Germany |
| 21 Jun | | Died | Georg Riedl † | Auxiliary Bishop of Regensburg, Germany |
| 2 Jul | | Died | Pedro Maldonado, O.F.M. † | Bishop of Mondoñedo, Spain |
| 30 Jul | 59.5 | Died | Honorato Juan † | Bishop of Osma, Spain |
| 31 Jul | 91.7 | Died | Bartolomé de las Casas (Casaus), O.P. † | Bishop Emeritus of Chiapas (Ciudad Real de Chiapas), Chiapas, México |
| 5 Aug | 61.7 | Died | Martín Pérez de Ayala † | Archbishop of Valencia, Spain |
| 16 Aug | | Died | Jerónimo Velasco † | Bishop of Oviedo, Spain |
| 19 Aug | | Appointed | Iñigo Avalos de Aragón, O.S. † | Bishop of Mileto, Italy | Cardinal, Bishop of Porto e Santa Rufina, Italy |
| 13 Sep | 27.8 | Died | Sigismund Markgraf von Brandenburg † | Archbishop-Elect Emeritus of Magdeburg, Germany |
| 13 Oct | | Ordained Bishop | Iñigo Avalos de Aragón, O.S. † | Bishop of Mileto, Italy | Cardinal, Bishop of Porto e Santa Rufina, Italy |
| 18 Oct | 11.8 | Appointed | Ernst Herzog von Bayern † | Bishop of Freising, Germany | Archbishop-Elect of Köln {Cologne}, Germany |
| Resigned | Moritz von Sandizell † | Bishop of Freising, Germany | Bishop Emeritus |
| 25 Oct | 58.0 | Resigned | Bernhard von Raesfeld † | Bishop-Elect of Münster, Germany | Bishop-Elect Emeritus |
| 26 Oct | 37.5 | Appointed | Johann Graf von Hoya zu Stolzenau † | Bishop of Münster, Germany |
| 11 Nov | | Appointed | Fernando de Barrionuevo, O.F.M. † | Bishop of Santiago de Chile |
| Born | José González Díez, O.P. † | Villadiezma | Archbishop of Burgos, Spain |
| 22 Nov | | Died | Domingo Cubels † | Bishop of Malta |
| 28 Nov | 58.2 | Died | Francisco Mendoza Bobadilla † | Cardinal, Archbishop of Burgos, Spain |
| Dec | | Died | Luís de la Fuente (Fuentes) † | Bishop of León en Nicaragua |
| 4 Dec | 72.0 | Died | Georg Herzog von Braunschweig-Lüneburg † | Archbishop-Elect of Bremen(-Hamberg), Germany |
| 9 Dec | 83.9 | Died | Fernando Valdés † | Archbishop of Sevilla {Seville}, Spain |
| 20 Dec | | Appointed | Pedro del Frago Garcés † | Bishop of Alghero, Italy | Bishop of Huesca, Spain |
| 23 Dec | 12.0 | Confirmed | Ernst Herzog von Bayern † | Bishop of Freising, Germany | Archbishop-Elect of Köln {Cologne}, Germany |