| Date | Age | Bishop | Title |
| unknown | | Juan Francisco de Aguirre † | Bishop of Tropea, Italy |
| unknown | | Jan Andruszewicz † | Bishop of Lutsk (Łuck), Ukraine |
| unknown | | Claude Briçonnet † | Bishop of Lodève, France |
| unknown | | Fausto Caffarelli † | Bishop of Fondi (Fundi), Italy |
| unknown | | Cesare Gesualdo † | Bishop of Mottola (Motula), Italy |
| unknown | | Giacomo de’ Giacomelli † | Bishop Emeritus of Belcastro, Italy |
| unknown | | Fabrizio Landriani † | Bishop of San Marco (Argentano), Italy |
| unknown | | Giulio Magnani, O.F.M. Conv. † | Bishop of Calvi Risorta, Italy |
| unknown | | Diego Gilberto Nogueras † | Bishop of Alife, Italy |
| unknown | | Nicola Angelo Olivieri † | Bishop of Acerno, Italy |
| unknown | | Lattanzio Roverella † | Bishop of Ascoli Piceno, Italy |
| unknown | | Quinzio de Rusticis † | Bishop of Mileto, Italy |
| unknown | | Martino Terracina † | Bishop of Bisignano, Italy |
| unknown | | Pedro Vaguer † | Bishop of Alghero, Italy |
| 6 Jan | 27.1 | Francesco Gonzaga † | Cardinal, Bishop of Mantova, Italy |
| 6 Jan | | Domenico Stella, O.P. † | Bishop of Capodistria (Capo d’Istria)(Koper), Slovenia |
| 15 Feb | | Giovanni Battista Orsini † | Archbishop of Santa Severina, Italy |
| Apr | | Simone Gattola † | Bishop of Venosa, Italy |
| 29 Apr | 63.3 | Jean Suau † | Cardinal, Bishop Emeritus of Mirepoix, France |
| 22 May | | Tommaso Scotti, O.P. † | Bishop of Terni, Italy |
| 21 Jun | | Georg Riedl † | Auxiliary Bishop of Regensburg, Germany |
| 2 Jul | | Pedro Maldonado, O.F.M. † | Bishop of Mondoñedo, Spain |
| 17 Jul | | Angelo Massarelli † | Bishop of Telese o Cerreto Sannita, Italy |
| 30 Jul | 59.5 | Honorato Juan † | Bishop of Osma, Spain |
| 31 Jul | 91.7 | Bartolomé de las Casas (Casaus), O.P. † | Bishop Emeritus of Chiapas (Ciudad Real de Chiapas), México |
| Aug | | Girolamo Michele Nichesola, O.P. † | Bishop of Teano, Italy |
| 5 Aug | 61.7 | Martín Pérez de Ayala † | Archbishop of Valencia, Spain |
| 16 Aug | | Jerónimo Velasco † | Bishop of Oviedo, Spain |
| 29 Aug | 66.7 | Francesco Crasso † | Cardinal, Cardinal-Priest of Sant’Eufemia |
| 13 Sep | 27.8 | Sigismund von Brandenburg † | Former Archbishop-Elect of Magdeburg, Germany |
| 16 Sep | 53.6 | Sebastiano Gualterio † | Bishop of Viterbo e Tuscania, Italy |
| 27 Sep | | Marco Gerolamo Vida, C.R.L. † | Bishop of Alba (Pompea), Italy |
| 6 Oct | 68.7 | Tiberio Crispo † | Cardinal, Cardinal-Bishop of Sabina |
| 10 Nov | | Giovanni Francisco de Gaeta † | Bishop of Ascoli Satriano, Italy |
| 14 Nov | 56.9 | Pier Francesco Ferrero † | Cardinal, Bishop Emeritus of Vercelli, Italy |
| 22 Nov | | Domingo Cubels, O.S.Io.Hieros. † | Bishop of Malta |
| Dec | | Luís de la Fuente (Fuentes) † | Bishop of Nicaragua |
| 1 Dec | 58.2 | Francisco Mendoza Bobadilla † | Cardinal, Bishop of Burgos, Spain |
| 4 Dec | 72.0 | Georg von Braunschweig-Lüneburg † | Archbishop-Elect of Bremen (and Hamberg), Germany |
| 9 Dec | 83.9 | Fernando Valdés † | Archbishop of Sevilla {Seville}, Spain |