| Date | Age | Bishop | Title |
| unknown | | Tommasi Balbani † | Bishop of Penne-Atri, Italy |
| unknown | | Albert de Bellièvre † | Archbishop Emeritus of Lyon, France |
| unknown | | Paolo Bisnetti † | Bishop of Trivento, Italy |
| unknown | 81.0 | Antonio Calderón de León † | Bishop of Santa Cruz de la Sierra, Bolivia |
| unknown | | Agustín de Carvajal, O.S.A. † | Bishop of Ayacucho o Huamanga, Peru |
| unknown | | Tomás Dávalos de Aragón † | Patriarch of Foreign Diocese |
| unknown | | Cesare Del Pezzo † | Bishop of Sulmona, Italy |
| 28 Jan | 68.4 | Camillo Borghese † | Pope (Roma {Rome}, Italy) |
| 10 Feb | 49.9 | Pietro Aldobrandini † | Cardinal, Archbishop of Ravenna, Italy |
| 27 Mar | 66.8 | Benedetto Giustiniani † | Cardinal, Bishop of Porto e Santa Rufina, Italy |
| Jun | 45.9 | Pedro Ruiz Valdivieso † | Bishop of Orense, Spain |
| 13 Jun | | Juan Zapata Osorio † | Bishop of Zamora, Spain |
| 18 Jun | 46.4 | Louis III de Guise † | Cardinal, Archbishop-Elect of Reims, France |
| Jul | | Agostinho Ribeiro † | Bishop of Angra, Portugal |
| 2 Sep | | Claudio Rangoni † | Bishop of Reggio Emilia, Italy |
| 8 Sep | | Pedro Carvajal Girón de Loaysa † | Bishop of Coria, Spain |
| 17 Sep | 79.0 | St. Roberto Francesco Romolo Bellarmino, S.J. † | Cardinal, Archbishop Emeritus of Capua, Italy |
| 24 Oct | 56.8 | Jean Davy Du Perron † | Archbishop of Sens, France |
| 7 Nov | 64.8 | Alfonso Márquez de Prado † | Bishop of Segovia, Spain |
| 10 Dec | 64.9 | Diego Torres Altamirano, O.F.M. † | Bishop of Cartagena, Colombia |
| 29 Dec | | Pedro Moncada † | Bishop of Gerona, Spain |