| Date | Age | Bishop | Title |
| unknown | | Giacomo Alfaridio † | Bishop of Città Ducale, Italy |
| unknown | | Ventura Benassai † | Bishop of Massa Marittima, Italy |
| unknown | | Pietro Matteo d’Aquino † | Bishop of Lecce, Italy |
| unknown | | Nicola Ippoliti † | Bishop of Ariano, Italy |
| unknown | 67.0 | Gabriele Maccafani † | Bishop of Marsi, Italy |
| unknown | | Francesco Manno † | Bishop of Ampurias e Civita, Italy |
| unknown | | Rinaldo Montoro e Landolina, O.P. † | Bishop of Cefalù, Italy |
| unknown | | Hermanus Nigenbroch, O.P. † | Titular Bishop of Lydda |
| unknown | | Nicolás (Pedro) de Noya, O.P. † | Bishop of Acerra, Italy |
| unknown | | Bernardino Orsini † | Bishop of Nocera de’ Pagani, Italy |
| unknown | | Giovanni Paternò, O.S.B. † | Archbishop of Palermo, Italy |
| unknown | | Giacomo Pisanelli † | Bishop of Scala, Italy |
| unknown | 63.0 | Heinrich Schertlin † | Auxiliary Bishop of Speyer, Germany |
| unknown | | Antonio Ursi † | Bishop of Canea (Cydonia, Egée), Greece |
| 13 Jan | | Dalmazio Gabrielli (Gabriele, Grazielli), O.P. † | Bishop of Siracusa, Italy |
| 20 Jan | 80.9 | Oliviero Carafa † | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| Feb | | Michel Bucy † | Archbishop of Bourges, France |
| 3 Mar | 32.2 | Louis d’Amboise (II) † | Cardinal, Bishop Emeritus of Albi, France |
| 27 Apr | 39.9 | Jakob von Baden † | Archbishop-Elect of Trier, Germany |
| 22 May | | François Desprez † | Bishop of Aosta, Italy |
| 24 May | 51.4 | Francesco Alidosi † | Cardinal, Bishop of Pavia, Italy |
| 3 Jun | 67.4 | Kaspar Tobritsch † | Auxiliary Bishop of Eichstätt, Germany |
| 15 Jun | | Johann Parkentin † | Bishop of Ratzeburg, Germany |
| 23 Aug | 61.6 | Francesco Argentino † | Cardinal, Bishop of Concordia (Sagittaria), Italy |
| 22 Sep | | Pietro Isvales † | Cardinal, Cardinal-Priest of Santa Pudenziana |
| 4 Oct | 39.8 | Pedro Luis de Borja Lanzol de Romaní, O.S.Io.Hieros. † | Cardinal, Archbishop of Valencia, Spain |
| 4 Nov | 70.8 | Francisco de Borja † | Cardinal, Archbishop of Cosenza, Italy |
| 5 Nov | 66.8 | Gabriele de’ Gabrielli † | Cardinal, Bishop of Urbino, Italy |
| 21 Nov | | Gonzalo Fernández de Heredia † | Archbishop of Tarragona, Spain |
| 4 Dec | 66.9 | Johann Rode † | Archbishop of Bremen (and Hamberg), Germany |