| Date | Age | Event | Bishop | Title | Current Title |
| 8 Feb 2001 | 54.5 | Appointed | Henryk Józef Nowacki | Titular Archbishop of Blera | Apostolic Nuncio to Nicaragua |
| 54.5 | Appointed | Henryk Józef Nowacki | Apostolic Nuncio to Slovakia | Apostolic Nuncio to Nicaragua |
| 19 Mar 2001 | 54.6 | Ordained Bishop | Henryk Józef Nowacki | Titular Archbishop of Blera | Apostolic Nuncio to Nicaragua |
| 17 Apr 2001 | 75.6 | Retired | Andrea Cordero Lanza di Montezemolo | Apostolic Nuncio to Italy | Cardinal, Archpriest of the Basilica di San Paolo fuori le Mura {Saint Paul Outside-the-Walls Basilica} |
| 75.6 | Retired | Andrea Cordero Lanza di Montezemolo | Apostolic Nuncio to San Marino | Cardinal, Archpriest of the Basilica di San Paolo fuori le Mura {Saint Paul Outside-the-Walls Basilica} |
| 31 Oct 2001 | 58.5 | Appointed | Jean-Paul Aimé Gobel | Apostolic Nuncio to Nicaragua | Apostolic Nuncio to Iran |
| 5 Feb 2002 | 75.0 | Retired | Paolo Giglio | Apostolic Nuncio to Egypt, Arab Republic of | Apostolic Nuncio Emeritus |
| 24 Jun 2002 | 54.9 | Appointed | David Albin Zywiec Sidor, O.F.M. Cap. | Auxiliary Bishop of Bluefields |
| 54.9 | Appointed | David Albin Zywiec Sidor, O.F.M. Cap. | Titular Bishop of Giru Marcelli | Auxiliary Bishop of Bluefields |
| 13 Sep 2002 | 55.2 | Ordained Bishop | David Albin Zywiec Sidor, O.F.M. Cap. | Titular Bishop of Giru Marcelli | Auxiliary Bishop of Bluefields |
| 15 Dec 2003 | 70.3 | Appointed | Bernardo Hombach Lütkermeier | Bishop of Granada |
| 76.5 | Retired | Leovigildo López Fitoria, C.M. | Bishop of Granada | Bishop Emeritus |
| 28 Oct 2004 | 39.5 | Appointed | René Sócrates Sándigo Jiron | Bishop of Juigalpa |
| 22 Jan 2005 | 39.8 | Ordained Bishop | René Sócrates Sándigo Jiron | Bishop of Juigalpa |
| 12 Feb 2005 | 50.6 | Appointed | Pedro Joaquin Hernández Cantarero, C.M.F. | Vicar Apostolic of Darién, Panama |
| 50.6 | Appointed | Pedro Joaquin Hernández Cantarero, C.M.F. | Titular Bishop of Thabraca | Vicar Apostolic of Darién, Panama |
| 19 Mar 2005 | 50.7 | Ordained Bishop | Pedro Joaquin Hernández Cantarero, C.M.F. | Titular Bishop of Thabraca | Vicar Apostolic of Darién, Panama |
| 1 Apr 2005 | 56.1 | Appointed | Leopoldo José Brenes Solórzano | Archbishop of Managua |
| 79.2 | Retired | Miguel Obando Bravo, S.D.B. | Archbishop of Managua | Cardinal, Archbishop Emeritus |
| 10 May 2005 | 56.4 | Appointed | Carlos Enrique Herrera Gutiérrez, O.F.M. | Bishop of Jinotega |
| 76.0 | Retired | Pedro Lisímaco de Jesús Vílchez Vílchez | Bishop of Jinotega | Bishop Emeritus |
| 31 May 2005 | 79.8 | Appointed | Andrea Cordero Lanza di Montezemolo | Cardinal, Archpriest of the Basilica di San Paolo fuori le Mura {Saint Paul Outside-the-Walls Basilica} |
| 24 Jun 2005 | 56.5 | Ordained Bishop | Carlos Enrique Herrera Gutiérrez, O.F.M. | Bishop of Jinotega |
| 15 Oct 2005 | 44.6 | Appointed | Jorge Solórzano Pérez | Bishop of Matagalpa |
| 3 Dec 2005 | 44.7 | Installed | Jorge Solórzano Pérez | Bishop of Matagalpa |
| 17 Dec 2005 | 75.9 | Retired | Gabriel Montalvo Higuera † | Apostolic Nuncio to United States of America | Apostolic Nuncio Emeritus |
| 24 Mar 2006 | 80.6 | Appointed | Andrea Cordero Lanza di Montezemolo | Cardinal-Deacon of S. Maria in Portico | Cardinal, Archpriest of the Basilica di San Paolo fuori le Mura {Saint Paul Outside-the-Walls Basilica} |
| 80.6 | Elevated to Cardinal | Andrea Cordero Lanza di Montezemolo | Cardinal, Archpriest of the Basilica di San Paolo fuori le Mura {Saint Paul Outside-the-Walls Basilica} |
| 17 Jul 2006 | 80.9 | Installed | Andrea Cordero Lanza di Montezemolo | Cardinal-Deacon of S. Maria in Portico | Cardinal, Archpriest of the Basilica di San Paolo fuori le Mura {Saint Paul Outside-the-Walls Basilica} |
| 2 Aug 2006 | 76.5 | Died | Gabriel Montalvo Higuera † | Apostolic Nuncio Emeritus to United States of America |
| 10 Oct 2007 | 64.4 | Appointed | Jean-Paul Aimé Gobel | Apostolic Nuncio to Iran |
| 14 Nov 2007 | 88.2 | Died | Pablo Antonio Vega Mantilla † | Bishop Emeritus of Juigalpa |
| 28 Nov 2007 | 61.3 | Appointed | Henryk Józef Nowacki | Apostolic Nuncio to Nicaragua |
| 1 Mar 2008 | 85.6 | Appointed | Lorenzo Antonetti | Cardinal-Priest of S. Agnese in Agone | Cardinal, President Emeritus of the Administration of the Patrimony of the Apostolic See |